Table 1 Effects of individual RNAis on C. elegans lifespan.
From: Branched-chain amino acid catabolism is a conserved regulator of physiological ageing
Effect on lifespan | Upregulated genes | Downregulated genes |
|---|---|---|
Shortened | sma-1, mod-5, mfb-1 | calu-1, spds-1, ssq-1, act-4, fat-7, act-1 |
Unchanged | mrp-2, cft-1, M116.2, cht-1 | cpn-2, tba-9, ifa-1, ost-1, ssq-4, ssq-3, ifc-1 |
Extended <5% | Y71G12B.31, ZC373.4 | plk-3, tba-6, ifb-2, F13A7.1, ifb-1, ifc-2, cyb-2.1 |
Extended ≥5% | fkh-7, csp-2, lgg-1, Y50C1A.1 | bcat-1, T25B9.1, ndk-1, ifd-1, tba-4, ifa-3, try-1, ifp-1 |
