Figure 3: Genetic signatures in inferred antigenic epitopes of norovirus GII.17 Kawasaki 2014. | Nature Communications

Figure 3: Genetic signatures in inferred antigenic epitopes of norovirus GII.17 Kawasaki 2014.

From: Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014

Figure 3

(a) Time-ordered SimPlot analysis of all complete and near complete norovirus GII.17 VP1 nucleotide sequences obtained in this study and GenBank. (b) Three-dimensional VP1 structure of the novel GII.17 Kawasaki 2014 predicted by homologous modelling based on the crystal structure of a GII.10 strain (PDB number 3V7A). Surface-exposed mutations and insertions, compared with other earlier local and regional GII.17 VP1 sequences collected in 2013–2014, are coloured in purple and magenta, respectively. (c) List of amino-acid changes in the P2 domain of the novel GII.17 Kawasaki 2014 compared with other earlier local and regional GII.17 VP1 sequences collected in 2013–2014. Surface-exposed mutations and insertions are highlighted as in b. Asterisk denotes residue under episodic diversifying (positive) selection. Number sign denotes residue insertion in the histo-blood group antigens binding interface. Parentheses refer to ‘in the vicinity of’ which is defined as 1 to 2 residues adjacent to antigenic epitopes inferred from those of GII.4 using multiple sequence alignment60. Residues are numbered with reference to the novel GII.17 Kawasaki 2014. JP, Japan; nt, nucleotide.

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