Figure 4: Neural responses to the captions task.
From: Corticostriatal pathways contribute to the natural time course of positive mood
Whole-brain analyses across groups revealed bilateral VS activation in response to the captions task compared with the descriptive task, at both the acute (a) and sustained (b) phases, at a significance level adjusted such that Type I error was controlled for all voxels in the brain using the false discovery rate (FDR), with q=0.05 in more than 10 contiguous voxels. Additional activations were found in language and semantic brain regions such as inferior frontal gyrus (IFG), superior temporal gyrus (STG), superior frontal gyrus (SFG) and temporal pole. (c) Mixed ANOVA revealed that in the control, but not rMDD group, VS activation in response to the captions task persisted during the sustained phase. For the sake of simplicity, only activations in response to the caption task are presented. (d) Across participants, the level of VS activation in response to the Sustained Phase Captions task was positively correlated with mood rating during the sustained phase. Bars ±1 s.e.m. *P<0.05. HC, healthy controls (n=25); rMDD, remitted individuals with a history of recurrent MDD (n=25); VS, ventral striatum.
