Figure 5: Corticostriatal effective connectivity at rest.
From: Corticostriatal pathways contribute to the natural time course of positive mood
(a) A single cluster within the DMN, located in the mPFC (226 voxels; MNI peak coordinates: X=10, Y=50, Z=32; Zscore=4.34; Pcorrected=0.045) exhibited a significant Group by Time (prior, following acute and following sustained) interaction with the VS time course at a significance level adjusted such that Type I error was controlled for all voxels in the DMN using the false discovery rate (FDR), with q=0.05 in more than 10 contiguous voxels. (b) Spectral-DCM analyses revealed that, before the mood induction (rest 1), the best fitting model for both groups was the one describing connectivity from the mPFC to the VS. Following the mood induction (rest 2 and rest 3), controls exhibited a change in their mPFC–VS effective connectivity pattern towards a more reciprocal relation, whereas rMDD maintained their original connectivity pattern throughout. HC, healthy controls (n=25); mPFC, medial prefrontal cortex; rMDD, remitted individuals with a history of recurrent MDD (n=25); VS, ventral striatum.
