Figure 1: Six1 transgenic tumours are genetically similar to GEMMs with p53 dysfunction. | Nature Communications

Figure 1: Six1 transgenic tumours are genetically similar to GEMMs with p53 dysfunction.

From: The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p

Figure 1

Gene expression microarrays from 377 GEMMs were hierarchically clustered based on an unbiased list of 11,868 gene probes. The dendrogram was coloured based on tumours with deficient p53 (C3Tag tumours (purple), p53null tumours (green)) and on Six1 tumours (red) and those with intact p53 function (black). Six1 transgenic tumours clustered on the same side of the dendrogram as all of the p53-deficient tumours.

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