Figure 1: Characteristics of the data.
From: Patterns and functional implications of rare germline variants across 12 cancer types
Data are distributed by age, cancer, cohort and carrier frequency. (a) Age of onset by cancer type. Average age varies across cancer types, from 43 years in LGG to 67.7 years in LUSC. Note that LGG, LUAD and STAD show clear bimodal characteristics. (b) Age distributions for discovery, validation and control cohorts. (c) Comparison of cancer gene truncation carrier frequencies across 12 cancer types. The distribution of rare germline truncation variants for 12 cancer types (represented as the per cent of cases in each cancer type with rare germline truncation mutation) in 2 different groups of cancer-associated genes (labelled on top of each bar plot): 114 cancer susceptibility genes from Rahman et al.1 and 47 genes associated with the DNA repair (Fanconi Anaemia) pathway3. There are 15 genes common to both groups. The total number of unique genes from these 2 groups is 131.
