Figure 5: The MGST2-LTC4 pathway triggers oxidative DNA damage.
From: Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage
(a,b) Immunostain of the oxidative DNA damage marker 8-OHdG in cells treated with vehicle or BfA in the absence or presence of pranlukast (pran.). Bar, 20 μm. n=3, ***P<0.0001. (c,d) Immunostain of the dsDNA break marker γ-H2AX in cells treated with vehicle or BfA in the absence or presence of BAY u9773. Bar, 20 μm. n=3, **P<0.005. Values in b and d represent the mean±s.d. Statistical significance was determined using one-way ANOVA.
