Figure 5: Interneuronal DISC1 knockdown increases interneuronal excitation. | Nature Communications

Figure 5: Interneuronal DISC1 knockdown increases interneuronal excitation.

From: Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex

Figure 5

(a) Representative current traces from PV interneurons infected with shRNA (control (Cont) or DISC1) in acute cortical slices from adult mice recorded in the whole-cell configuration. Negative peaks represent mEPSCs. Scale bars, x axis, 500 ms, y axis, 20 pA. (b) Quantification of mEPSC frequency in recordings from PV interneurons infected with shRNA (Cont or DISC1). DISC1 knockdown led to an increase in mEPSC frequency. (c) Quantification of mEPSC amplitude in recordings from PV interneurons infected with shRNA (Cont or DISC1). DISC1 knockdown did not affect mEPSC amplitude. Data are represented as mean±s.e.m. *P<0.05. N=5 animals, 27 cells for DISC1 shRNA, 4 animals, 20 cells for Cont shRNA.

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