Figure 3: Ingenuity Pathway Analysis outlines potential regulatory networks around EFEMP1 and WT1. | Nature Communications

Figure 3: Ingenuity Pathway Analysis outlines potential regulatory networks around EFEMP1 and WT1.

From: A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

Figure 3

Network Analysis for EFEMP1 and WT1 was carried out using the RNA-seq FPKM>30 gene list (see Methods section). WT1 regulates many extracellular matrix genes, including MMP2 (matrix metalloproteinase-2) and CTGF (connective tissue growth factor). EFEMP1 directly interacts with ELASTIN, a component of elastic fibres in the ECM. TIMP3 (tissue inhibitor of metalloproteinase-3), which is activated by WT1 and interacts with EFEMP1 and was found to connect between the two networks.

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