Figure 5: BPTF expression correlates with c-MYC signatures in human tumours.
From: BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
(a) Venn diagram showing the overlap of the c-MYC signatures used in the following analyses. (b) Dot plot of normalized enrichment scores (NES) of the four c-MYC signatures based on GSEA. NES values were calculated for each data set previously ranked-ordered by either BPTF or c-MYC levels. (c) Volcano plots of NES and enrichment P values of c-MYC signatures based on GSEA. NES values were calculated for each data set previously ranked-ordered by BPTF, c-MYC, N-MYC or L-MYC mRNA levels. Filled circles represent gene sets with a false discovery rate <0.25.
