Figure 1: Phylogenetic placement and orthology comparison among Cimex lectularius and other arthropod species.
From: Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
The phylogenetic analysis places C. lectularius as a sister species to another hemipteran, Acyrthosiphon pisum. The phylogeny is built using RAxML and it is based on the 1,734 single-copy orthologues that are present in all eight species. All nodes in the phylogenetic tree have 100% bootstrap support, while the branch length unit is substitutions per site. There are 1,734 genes that are present as single copy in all eight species tested. Another 4,187 of the C. lectularius genes are found in varying copy number in the other seven species, while 2,433 are found in the majority of species (that is, in 5–7 species) and 2,153 genes are found in ≥2 species (that is, in 2–4 species). Moreover, 1,147 genes have an orthologue in an arthropod other than the selected seven species. Last, 2,285 genes are lineage specific and do not have an orthologue in any other arthropod species.
