Figure 2: Conservation among HpuA homologues.
From: Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family
(a) Cartoon representation of KdHpuA (oriented as in Fig. 1b) with residues coloured according to sequence conservation: blue for the most conserved, through to red for the least conserved. Conservation scores generated by Consurf69. (b) Sequence alignment of HpuA homologues from N. gonorrhoeae (Ng), N. meningitidis (Nm), Neisseria lactamica (Nl), Neisseria mucosa (Nmu), Neisseria sicca (Ns), E. corrodens (Ec) and K. denitrificans (Kd). Boxes enclose the loop regions mentioned in the text, blue circles beneath the alignment indicate KdHpuA residues observed to interact with Hb and hydrophobic side chains on loop-1, loop-4 and loop-5 are coloured red.
