Figure 1: Patterns of gonadotropin secretion in agonadal male monkeys.
From: Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression
(a,c) Infant (INF)–juvenile (JUV) transition. Time courses of circulating concentrations of LH (a) and FSH (c) in 10 individual monkeys bilaterally orchidectomized at 2–6 days of age. Data for animals comprising the infantile (INF; n=5) and early juvenile (EJ; n=5) groups are shown by the closed and open data points, respectively. Block and line arrowheads indicate age at which the hypothalamus was collected from INF and EJ animals, respectively. (b,d) Juvenile (JUV)–pubertal (PUB) transition. Time courses of circulating concentrations of LH (b) and FSH (d) in 10 individual monkeys bilaterally orchidectomized at 16–18 months of age. Data for animals comprising the early pubertal (EP; N=4) and late pubertal (LP; n=2) groups are shown by the closed and open data points, respectively. Data for late juveniles (LJ) (n=4) are shown in open triangles—note these are largely masked by the closed data points. Block, line and square arrowheads indicate age at which the hypothalamus was collected from LJ, EP and LP animals, respectively. Thicker arrows are the result of two animals with overlapping ages.
