Figure 4: Rescue of lower PHLPP2 in aging or obesity reduces lipogenesis.
From: mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
(a) Liver mRNA expression from young and adult mice (n=6 per each group). (b–d) Western blot from livers of young and adult (b), chow- and HFD-fed (c), or lean and ob/ob (d) mice, normalized to β-actin. (e–h) Western blots from liver (e), hepatic triglyceride (f), liver lipogenic gene expression (g) and plasma lipids (h) in adult, HFD-fed Ad-GFP or Ad-PHLPP2 mice (n=6–7/group). *P<0.05, **P<0.01 as compared with the indicated control by two-way analysis of variance. All data are shown as the means±s.e.m.
