Figure 3: BioAge predicts HBV vaccine response. | Nature Communications

Figure 3: BioAge predicts HBV vaccine response.

From: Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Figure 3

(a) BioAge classification of the 135 elderly patients based on gene expression prior to vaccination is significantly associated with the response to HBV vaccination. Each bar of the bar plot represents one of the elderly participants in the EM131 cohort. The height of the bar indicates the BioAge score of that donor. Bars were ordered by increasing level of the BioAge, separately for the HBV poor-responders (in red) and HBV responders (in black). Fisher’s exact test P values are given on the plot. (b) Forward selection among the modules composing the BioAge signature resulted in the selection of modules M1 and M16 as optimal signatures, predicting HBV vaccine response in the EM131 elderly cohort (age≥65). (c) Pathway enrichment analysis on the genes included in modules M1 and M16 using the IPA canonical pathway database. Fisher exact test was performed to assess statistical enrichment and gene sets with FDR-corrected P value≤0.05 are presented.

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