Figure 6: Integrative analysis reveals positive correlations between biomarkers of HBV vaccine response. | Nature Communications

Figure 6: Integrative analysis reveals positive correlations between biomarkers of HBV vaccine response.

From: Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Figure 6

A projection-based multivariate approach was adopted to assess the correlation between transcriptomic, FCM, haematologic and cytokine/chemokine expression data sets. Least-square regressions between pairs of data sets was performed using the R package ‘mixOmics’. The resulting regression coefficients were converted to Pearson’s correlations between pairs of features of the different data sets (presented at each quadrant of the figure). Significant (t-test: r≥0.188, P≤0.05) positive correlations are presented as edges and the features as vertices. The vertices are coloured by fold-change between HBV vaccine responders versus poor-responders of the EM131 training set.

Back to article page