Figure 7: TS effects on Ca2+ transient amplitudes.
From: Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation
(a) The LRd model was used to gauge TS mutation effects on Ca2+ transient amplitudes. Data corresponds to the same simulations run in Fig. 5. Increasing the fraction of G406R channels increased the average Ca2+ transient amplitude (red circles). (+) indicates minimum and maximum amplitudes for an individual simulation. (b) Increasing the fraction of G402S channels also increased the average Ca2+ transient amplitude (blue circles) but with a shallower dependence on the fraction of channels.
