Figure 5: Mouse CNS tumours reflect the diversity of human RTs. | Nature Communications

Figure 5: Mouse CNS tumours reflect the diversity of human RTs.

From: The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

Figure 5

(a) Differential subgroups were identified using ConsensusClusterPlus R package v1.18.0 (with 1,000 resamplings, average linkage hierarchical clustering algorithm and Pearson correlation distance), based on the expressed and variable genes obtained after elimination of background (threshold: 1.2) and invariant genes using RIQR (threshold: 0.75; max(Q3−Q2,Q1−Q2)/Q2). Mb, mice medulloblastomas (Ptch1+/− model, n=3); Nb, mice neuroblastomas (Th-Mycn model, n=4); lymph, CD8(+) T-cell lymphomas (n=7); mIC, murine intra-cranial tumours (n=5); mE/IC (n=4). (b) Differential subgroups among human tumours were identified by ConsensusClusterPlus R package, as aforementioned. hIC group (human intracranial) consists of 28/28 intracranial tumours and is dissected in three subgroups (hIC1, hIC2 and hIC3). hEC group (human extracranial tumours) consists of 20/22 extracranial tumours and 2/22 intracranial tumours. MB: medulloblastomas, SHH subtype; NB: MYCN-amplified neuroblastomas. (c) AGDEX score performed on each mouse and human subgroups. (d) Left panel: clustering on a set of 540 genes (268+98+42+132) whose higher expression levels specifically define hEC, hIC1, hIC2 and hIC3, respectively; the list is obtained by pair-wise Welch t-test (P≤0.05) analyses, and limited to genes with a fold change |FC|≥1.2 (log2 expression value). Right panel: clustering on the two mouse subgroups using the ortholog genes.

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