Figure 2: Modelling of HsCaM KMT as a class I MT. | Nature Communications

Figure 2: Modelling of HsCaM KMT as a class I MT.

From: Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin

Figure 2

Molecular model of the catalytic core of HsCaM KMT (Isoform 1) built using ESyPred3D14 and based on the homology with ribosomal L11 protein lysine methyltransferase (PrmA; 2ZBQ.pdb chain A). The loops highlighted in red denote the putative AdoMet-binding site. This figure was rendered using PyMOL (http://www.pymol.org/). In the ribbon representation of the catalytic domain of HsCaM KMT, Motif I (residues 149–158) is shown in blue, Post-Motif I (residues 174–180) in green, Motif II (residues 225–233) in teal and Motif III (residues 234–262) in purple, and are defined according to Petrossian and Clarke13. For clarity, only residues 97–291 are depicted.

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