Figure 6: Reduced expression level of TRAIP in human lung adenocarcinoma.
From: TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage
(a) Immunohistochemical staining of TRAIP in human lung cancer patient tissues and matched normal adjacent tissues. Red squares indicate the magnified region shown to the right panel. (b) Box-and-Whisker plots of nuclear TRAIP H-scores in lung adenocarcinomas and matched normal adjacent tissues. P<0.0001 (n=72 for tumour; n=71 for normal adjacent tissues). (c) Immunohistochemical staining of TRAIP and γH2AX in human lung cancer patient tissues. Enhanced γH2AX foci in the patient tissues with lower nuclear expression of TRAIP (upper panel) and few γH2AX foci in the tissues with higher nuclear expression of TRAIP (lower panel). Black squares indicate the magnified region shown to right panel. Scale bar, 50 μm. (d) Pearson correlation coefficient between nuclear TRAIP expression and percentage of cells with γH2AX foci. Graph presents the scatter plot of H-score of nuclear TRAIP (y axis) and cell percentage with γH2AX foci (x axis). P<0.05 (n=64).
