Figure 4: DNA methylation patterns across genomic features.
From: Evolutionary signals of selection on cognition from the great tit genome and methylome
(a) Non-CpG methylation patterns associated with CpG islands and gene bodies. (b) Neuronal CpG methylation in gene bodies and at TSS is negatively correlated with expression (Spearman’s rank correlation, Spearman’s rho <−0.23, P<1.0 × 10−95 for all comparisons), presented as fragments per kilobase of transcript per million fragments mapped (FPKM). (c) Neuronal non-CpG methylation at TSS, gene bodies and adjacent upstream and downstream regions is negatively correlated with expression (Spearman’s rho <−0.23, P<1.0 × 10−95 for all comparisons). (d) Increased neuronal CpG methylation at sweep gene bodies (Linear Mixed Effect Model, LMM; 
, P=9.2 × 10−88) and adjacent upstream (LMM; 
, P=3.0 × 10−34) and downstream regions (LMM; 
, P=1.8 × 10−65). (e) Decreased neuronal non-CpG methylation in sweep gene bodies (LMM; 
, P=4.0 × 10−14) and adjacent upstream (LMM; 
, P=0.001) and downstream regions (LMM; 
, P=1.64 × 10−8). Shaded areas denote variances.
