Figure 5: Genome-wide expression changes on Rcor2 depletion in mouse developing cortex by RNA-seq analysis.
From: LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
(a,b) Scatter plot analysis of genome-wide expression profiles of Rcor2cko versus Rcor2fl/fl samples at E13.5 (a) and E15.5 (b). Dots above or below the dash line indicate upregulated or downregulated genes on Rcor2 depletion, respectively. Red dots or green dots highlight the significantly differentially expressed genes on Rcor2 depletion. Raw counts (x axis); gene expression fold changes on Rcor2 depletion (y axis). (c) Venn diagrams of upregulated genes (left) and downregulated genes (right) in Rcor2cko samples compared with Rcor2fl/fl samples. (d) The profiles of Rcor2 and H3k4me1 enrichments analysed in ChIP-seq results shown in Fig. 3 in regulatory regions of genome-wide scale (red) and of the upregulated genes (purple) according to RNA-seq results. (e) Correlation network of overlapped upregulated genes in both E13.5 and E15.5 samples. Lines indicate the correlations between two connected genes with R>0.55. Genes were analysed by GO analysis and divided into different categories.
