Table 3 Association of chromosome 5q14.1 locus with choline pathway metabolites.

From: Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Metabolite

rs16876394

rs557302

rs617219

 

Beta±s.e.

(n)

P-value

Beta±s.e.

(n)

P-value

Beta±s.e.

(n)

P-value

Choline (μM)

−0.004±0.013

(n=3,580)

0.74

−0.008±0.008

(n=3733)

0.32

0.001±0.008

(n=3720)

0.90

TMAO (μM)

−0.011±0.030

(n=3,659)

0.72

−0.006±0.080

(n=3814)

0.74

−0.012±0.018

(n=3802)

0.52

Betaine (μM)

−0.093±0.014

(n=3,674)

7.2 × 10 −12

−0.052±0.008

(n=3829)

8.2 × 10 −11

0.059±0.008

(n=3816)

7.2x10 −13

Homocysteine (μM)

−0.017±0.017

(n=1,964)

0.31

−0.011±0.010

(n=1999)

0.26

−0.008±0.010

(n=1997)

0.44

Methionine (μM)

0.069±0.028

(n=398)

0.02

0.021±0.018

(n=399)

0.25

0.013±0.019

(n=397)

0.50

Dimethylglycine (μM)

0.064±0.043

(n=396)

0.14

0.091±0.027

(n=397)

6.1 × 10 −4

−0.103±0.029

(n=395)

3.9 × 10 −4

Sarcosine (μM)

0.052±0.051

(n=398)

0.31

0.053±0.032

(n=399)

0.10

−0.023±0.035

(n=397)

0.50

Glycine (μM)

0.038±0.034

(n=398)

0.27

0.030±0.021

(n=399)

0.16

−0.003±0.023

(n=397)

0.89

  1. TMAO, trimethylamine N-oxide.
  2. Betas±s.e. and P-values for the minor alleles of rs16876394 (C), rs557302 (A), and rs617219 (C) were obtained by linear regression using natural log transformed values, assuming an additive genetic model, and with adjustment for age and sex. Significant associations at a Bonferroni-corrected threshold of P<2.1 × 10-3 (0.05/3 SNPs × 8 metabolites) are highlighted in bold.
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