Table 2 Selected loci with differential methylation in cord blood in relation to maternal folate.

From: Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

CHR	Position	CpG	Gene	Gene group	MoBa			Generation R				Meta-analysis
					Coef	s.e.	P	Coef	s.e.	P	Weighted mean beta	Coef	s.e.	P
7	126698829	cg15908975	GRM8	Body	−0.012	0.003	8.26E−06	−0.015	0.007	2.46E−02	0.54	−0.012	0.002	6.76E−07
7	126889015	cg18574254	GRM8	5′-UTR	−0.010	0.002	3.25E−06	−0.011	0.003	2.40E−04	0.84	−0.011	0.002	3.27E−09
10	91296252	cg22591480	SLC16A12	TSS1500	−0.009	0.002	1.96E−04	−0.008	0.003	2.33E−02	0.85	−0.008	0.002	1.34E−05
10	91296311	cg14920044	SLC16A12	TSS1500	−0.011	0.003	6.45E−05	−0.011	0.005	2.31E−02	0.78	−0.011	0.003	4.31E−06
11	132951838	cg24829292	OPCML	Body	0.008	0.003	9.45E−03	0.014	0.004	7.55E−05	0.44	0.010	0.002	6.60E−06
11	132951861	cg22629528	OPCML	Body	0.015	0.005	5.45E−03	0.031	0.009	4.54E−04	0.60	0.019	0.005	2.91E−05
11	132951950	cg26283170	OPCML	Body	0.006	0.002	9.46E−03	0.015	0.004	4.58E−05	0.54	0.009	0.002	1.30E−05
12	49689685	cg24804179	PRPH	Body	−0.007	0.002	3.73E−05	−0.007	0.004	8.72E−02	0.20	−0.007	0.002	8.05E−06
12	49690254	cg05775627	PRPH	Body	−0.006	0.002	3.61E−03	−0.007	0.002	7.87E−04	0.63	−0.007	0.002	1.01E−05
12	49692283	cg16010628	PRPH	3′-UTR	−0.006	0.001	8.58E−06	−0.002	0.003	4.51E−01	0.29	−0.005	0.001	1.73E−05
16	2866901	cg05635274	PRSS21	TSS1500	0.008	0.002	1.79E−04	0.013	0.005	5.05E−03	0.82	0.009	0.002	4.77E−06
16	2867051	cg02296564	PRSS21	TSS200	0.011	0.003	7.43E−04	0.011	0.004	2.63E−03	0.64	0.011	0.003	6.21E−06
16	2867434	cg22730830	PRSS21	Body	0.012	0.003	2.69E−04	0.016	0.005	4.02E−03	0.59	0.013	0.003	3.99E−06
16	2867446	cg01232511	PRSS21	Body	0.012	0.004	9.50E−04	0.020	0.006	2.32E−03	0.67	0.014	0.003	1.23E−05
17	35285205	cg10612259	LHX1		−0.009	0.003	1.91E−04	−0.015	0.004	5.54E−05	0.47	−0.011	0.002	9.10E−08
17	35285295	cg01965477	LHX1		−0.002	0.001	5.26E−04	−0.003	0.001	8.80E−03	0.06	−0.002	0.001	2.09E−05
19	1453909	cg11775595	APC2	Body	−0.017	0.003	8.04E−07	−0.010	0.005	3.57E−02	0.44	−0.015	0.003	1.64E−07
19	1456246	cg14907738	APC2	Body	−0.006	0.001	3.59E−05	−0.005	0.003	9.34E−02	0.22	−0.006	0.001	8.57E−06
19	1456337	cg27150178	APC2	Body	−0.009	0.002	6.01E−06	−0.007	0.003	3.00E−02	0.32	−0.009	0.002	5.81E−07
19	1456886	cg03165176	APC2	Body	−0.012	0.003	1.96E−04	−0.012	0.005	2.62E−02	0.58	−0.012	0.003	1.44E−05
19	1457211	cg14559388	APC2	Body	−0.003	0.001	3.49E−05	−0.002	0.001	4.52E−02	0.05	−0.003	0.001	4.98E−06
19	1465207	cg04624885	APC2	Body	−0.016	0.003	3.08E−07	−0.003	0.003	4.43E−01	0.66	−0.010	0.002	1.56E−05
19	1472936	cg19870717	APC2	3′-UTR	−0.010	0.002	1.81E−08	−0.006	0.003	4.46E−02	0.37	−0.009	0.002	4.64E−09
19	1473042	cg16613938	APC2	3′-UTR	−0.017	0.003	1.15E−07	−0.011	0.006	7.00E−02	0.71	−0.016	0.003	3.05E−08
19	1473179	cg23291200	APC2	3′-UTR	−0.011	0.002	7.81E−08	−0.008	0.003	3.92E−03	0.63	−0.010	0.002	1.72E−09
19	51415450	cg13793157	KLK4		−0.009	0.002	2.85E−04	−0.009	0.005	5.41E−02	0.53	−0.009	0.002	4.00E−05
19	51415452	cg10078829	KLK4		−0.007	0.002	1.89E−04	−0.007	0.003	3.57E−02	0.40	−0.007	0.002	1.84E−05

CHR, chromosome; Coef, regression coefficient from statistical model; gene, mapped or nearest gene (within 10 Mb) symbol using the UCSC database and Snipper software; gene group, gene region feature category (UCSC with verification); P, uncorrected P value from statistical model; UTR, untranslated region; weighted mean beta, average of the mean methylation beta values for MoBa and Generation R cohorts, weighted by cohort sample size.
Selection limited to genes with at least two CpGs at FDR significance that were prioritized for discussion.
Meta-analysis of results for 1,275 MoBa participants and 713 Generation R participants. Robust linear regression models adjusted for maternal age, maternal education, maternal sustained smoking during pregnancy, parity and batch. Results sorted by the chromosome and position of the CpG sites listed. For complete list of CpGs differentially methylated in relation to maternal folate and for results from meta-analysis models unadjusted for covariates and adjusted for covariates and cell type see Supplementary Data 1 (sorted by P value) and 2 (sorted by chromosome, position). Supplementary Data include columns for mapped and nearest gene for each CpG.

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Table 2 Selected loci with differential methylation in cord blood in relation to maternal folate.

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