Figure 4: Accumulation of glycerol phosphate and rapid ATP depletion in PI-treated M. tuberculosis. | Nature Communications

Figure 4: Accumulation of glycerol phosphate and rapid ATP depletion in PI-treated M. tuberculosis.

From: A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Figure 4

(a) MIC50 values of glycerol phosphate (black squares), DHAP (blue triangles) and methylglyoxal (red diamonds) were determined for M. tuberculosis H37Rv. M. tuberculosis H37Rv was exposed to 1 and 2 in the presence of glycerol for 24 h. The relative abundances of glycerol phosphate (b) and of pyruvate (c) are shown. M. tuberculosis H37Rv was exposed to 1 and 2 in the presence of glycerol for 24 h. The intracellular ATP level was quantified (d). Streptomycin and moxifloxacin were used as reference compounds.

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