Table 1 Structure and biological activity of the PI compounds.

From: A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

  

MIC50 (μM)

CC50_BHK21 (μM)

CC50_HepG2 (μM)

1

0.75±0.32

>50

>50

2

0.57±0.23

>50

>50

3

0.036±0.04

>50

>50

4

0.21±0.01

ND

ND

  1. Abbreviations: CC50, cytotoxic concentration 50%; MIC50, minimum inhibitory concentration 50%; ND, not determined.
  2. The MIC50 was determined against M. tuberculosis H37Rv. Cytotoxicity (CC50) was determined in two cell lines, BHK21 and HepG2. Assays were carried out at least two times in triplicates.
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