Table 1 SEMA4A rs76381440 (p.Pro682Ser, c.2044C>T) and rs148744804 (p.Gly484Ala, c.1451G>C) genotype counts and association statistics for the six colorectal cancer case–control studies.
From: Correspondence: SEMA4A variation and risk of colorectal cancer
Study | Case | Control | OR (95% CI) | P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AB | BB | Total | MAF | AA | AB | BB | Total | MAF | |||
(A) rs76381440 | ||||||||||||
England and Wales | 0 | 152 | 3,514 | 3,666 | 0.021 | 2 | 259 | 5,879 | 6,140 | 0.021 | 0.97 (0.79–1.20) | 0.80 |
Scotland | 0 | 99 | 1,953 | 2,052 | 0.024 | 1 | 84 | 1,919 | 2,004 | 0.021 | 1.14 (0.85–1.54) | 0.37 |
Holland | 0 | 12 | 399 | 411 | 0.015 | 0 | 10 | 380 | 390 | 0.013 | 1.14 (0.49–2.68) | 0.76 |
Spain | 0 | 12 | 264 | 276 | 0.022 | 0 | 10 | 274 | 284 | 0.018 | 1.25 (0.53–2.93) | 0.62 |
Portugal | 0 | 1 | 198 | 199 | 0.003 | 0 | 7 | 179 | 186 | 0.019 | 0.13 (0.02–1.06) | 0.06 |
Germany | 0 | 9 | 243 | 252 | 0.018 | 0 | 27 | 1,060 | 1,087 | 0.012 | 1.44 (0.68–3.13) | 0.34 |
Combined | 0 | 285 | 6,571 | 6,856 | 0.021 | 3 | 397 | 9,691 | 10,091 | 0.020 | 1.04 (0.89–1.22) | 0.63 |
(B) rs148744804 | ||||||||||||
England/Wales | 0 | 8 | 3,658 | 3,666 | 0.0011 | 0 | 13 | 6,127 | 6,140 | 0.0011 | 1.03 (0.43–2.49) | 0.95 |
Scotland | 0 | 6 | 2,046 | 2,052 | 0.0015 | 0 | 5 | 1,999 | 2,004 | 0.0012 | 1.17 (0.36–3.85) | 0.79 |
Holland | 0 | 0 | 411 | 411 | 0.0000 | 0 | 1 | 389 | 390 | 0.0013 | NA | NA |
Spain | 0 | 2 | 274 | 276 | 0.0036 | 0 | 1 | 283 | 284 | 0.0018 | 2.07 (0.19–22.9) | 0.56 |
Portugal | 0 | 1 | 198 | 199 | 0.0025 | 0 | 0 | 186 | 186 | 0.0000 | NA | NA |
Germany | 0 | 0 | 252 | 252 | 0.0000 | 0 | 0 | 1,087 | 1,087 | 0.0000 | NA | NA |
Combined | 0 | 17 | 6,839 | 6,856 | 0.0012 | 0 | 20 | 10,071 | 10,091 | 0.0010 | 1.14 (0.58–2.24) | 0.71 |
