Table 2 Events and follow-up by BB intake.

From: Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Event

No BB no. (%)

BB no. (%)

P value*

HR (95% CI) †

P value †

At risk

863

93

   

First events

 Lymph node metastasis

47 (5.5)

1 (1.1)

0.07

0.13 (0.02–0.97)

0.04

 Distant metastasis

131 (15.2)

6 (6.5)

0.04

0.40 (0.17–0.93)

0.03

 Local recurrence

68 (7.9)

6 (6.5)

0.74

0.93 (0.39–2.25)

0.93

 Local or regional or distant

246 (28.5)

13 (14.0)

<0.01

0.48 (0.25–0.79)

<0.01

Overall mortality

 Death from breast cancer

161 (18.9)

8 (8.6)

0.03

0.48 (0.23–0.99)

0.05

 Death from other or missing causes

48 (5.6)

10 (10.8)

0.02

1.75 (0.84–3.62)

0.13

Follow-up

 Months, median (Q1–Q3)

78 (46–109)

77 (47–105)

0.91

  
  1. CI, confidence interval; HR, hazard ratio; Q1, lower quartile; Q3, upper quartile.
  2. *Univariate analysis: association between number of events and BB use was tested by the Gray test, while association between follow-up and BB use was tested by the median two-sample test.
  3. †HRs and P values for testing BB versus non-BB were obtained using a Cox regression multivariable model that included age, tumour size, lymph node status, peritumoural vascular invasion, type of surgery, radiotherapy, other cardiac medications and statins.
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