Figure 3: Maternal deletion of Ube3a has no apparent effect on intrinsic excitability and inhibitory input onto VTA neurons. | Nature Communications

Figure 3: Maternal deletion of Ube3a has no apparent effect on intrinsic excitability and inhibitory input onto VTA neurons.

From: Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Figure 3

(a) Representative traces and average data showing action potential firing rates to increasing current injections in Ai9-positive VTA neurons in THCRE::Ai9::Ube3am−/p+ and THCRE::Ai9::Ube3am+/p+ mice (n=18 per group, Student’s t-test, P=0.70). (b) Average values of resting membrane potential (Student’s t-test, P=0.46), membrane resistance (P=0.25), maximum instantaneous firing frequency (Student’s t-test, P=0.22), and average action potential peak amplitude (Student’s t-test, P=0.32) of Ai9-positive neurons. (c) Representative traces and average data showing the frequency and amplitude of sIPSCs in Ai9-positive neurons (n=12 for each genotype, Student’s t-test, P=0.42, P=0.24). GABAergic currents were validated by bath application of SR95531. All bars represent mean±s.e.m.

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