Figure 2: Two configurations in the ATPγS–CMG–DNA complex. | Nature Communications

Figure 2: Two configurations in the ATPγS–CMG–DNA complex.

From: Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Figure 2

(a) AAA+, side and cut-through view of the CMG in a relaxed ATPase configuration. Cdc45 topologically locks the Mcm5-2 gate. (b) AAA+, side and cut-through N-terminal view of the CMG in a compact ATPase configuration. DNA density surmounting the AAA+ domain has been removed for visualization purposes (also see Fig. 4).

Back to article page