Figure 2: Protein domains depleted or enriched in Pneumocystis.

Significantly enriched (top panel) or depleted (lower panel) Pfam domains (Fisher’s exact test, q value<0.05) are included in the heat map if the domains appear at least twice in the following comparisons: Pneumocystis versus Schizosaccharomyces, Pneumocystis versus Schizosaccharomyces and T. deformans, Pneumocystis versus S. cerevisiae and C. albicans, Pneumocystis versus E. cuniculi and E. intestinalis, Pneumocystis versus all others shown. Broader functional categories of proteins are indicated on the left, while specific Pfam domains are listed on the right. The number of proteins containing each domain is indicated within each box for each species. The heat map is colour coded based on a Z score, as indicated by the key at the bottom right. Fungal species are ordered based on their phylogenetic relationship as indicated at the bottom.