Figure 4: Reduction of carbohydrate and lipid metabolism in Pneumocystis.

A condensed version of pathways highlights retained (green arrows) and lost (grey arrows) pathways. Enzymes and membrane transporters absent in all three Pneumocystis species are highlighted in red font; those retained in all three species are highlighted in blue. Yellow and grey boxes indicate metabolites present and absent, respectively. Some metabolites are included more than once as they interact with multiple pathways, in which case the yellow or grey colouring refers to their role in different pathways. Enzyme Sur2 (in pink) is present in only P. murina but not P. carinii or P. jirovecii. Enzyme Mct1 (in pink) is present in both P. murina and P. carinii but not P. jirovecii. The boxed question mark (‘?’) leading to inositol indicates a hypothetical enzyme. The names of enzymes, transporters and metabolites follow the standard abbreviated names for S. cerevisiae. The enzyme and transporter names containing two or more digits represent duplicated enzymes and transporters.