Table 1 Haplotype (a) and genotype (b)* association study between NLRC4 and Aspergillus infection; (c)† best models assessed by the GMDR for one to five-way combinations, to test gene–gene interactions in determining Pseudomonas infection.

From: IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(a)

NLRC4 Haplotype‡

NLRC4 SNPs

Asp−

Asp+

OR

P value

 

rs212704

rs455060

rs7562653

rs385076

    

H1

A

T

C

C

122 (40.8%)

34 (47.6%)

Reference

 

H2

G

C

T

T

72 (24.1%)

20 (28.0%)

0.875

0.729

H3

G

T

C

C

39 (13.1%)

8 (10.8%)

0.812

0.644

H4

G

C

C

T

32 (10.7%)

1 (1.4%)

0.169

0.177

H5

G

C

C

C

11 (3.8%)

1 (1.4%)

0.387

0.452

H6

A

T

T

C

8 (2.7%)

—

0.000

0.268

H7

A

C

T

T

5 (1.7%)

4 (5.3%)

2.930

0.025

H8

A

T

T

T

4 (1.4%)

1 (1.4%)

0.854

0.995

H9

A

T

C

T

1 (0.4%)

1 (1.4%)

4.879

0.234

H10

G

C

T

C

—

1 (1.4%)

9.989e+013

0.149

(b)

Status

NLRC4 rs212704

A/G OR ( P -value)

G/G OR ( P -value)

Global P -value

 

A/A (%)

A/G (%)

G/G (%)

   

Asp−

39 (22.9%)

83 (48.8%)

48 (28.2%)

0.996 (0.174)

0.303 (0.030)

0.071

Asp+

9 (25.0%)

23 (63.9%)

4 (11.1%)

   
 

NLRC4 rs455060

C/T OR ( P -value)

T/T OR ( P -value)

Global P -value

Status

C/C (%)

C/T (%)

T/T (%)

   

Asp−

20 (12.2%)

90 (54.9%)

54 (32.9%)

0.750 (0.778)

0.774 (0.951)

0.881

Asp +

6 (15.4%)

21 (53.9%)

12 (30.8%)

   
 

NLRC4 rs7562653

C/T OR ( P -value)

T/T OR ( P -value)

Global P -value

Status

C/C (%)

C/T (%)

T/T (%)

   

Asp−

83 (46.6%)

79 (44.4%)

16 (9.0%)

1.161 (0.691)

1.009 (0.900)

0.924

Asp +

15 (37.5%)

21 (52.5%)

4 (10.0%)

   
 

NLRC4 rs385076

C/T OR ( P -value)

T/T OR ( P -value)

Global P -value

Status

C/C (%)

C/T (%)

T/T (%)

   

Asp−

61 (35.1%)

86 (49.4%)

27 (15.5%)

1.334 (0.260)

0.643 (0.274)

0.415

Asp +

11 (28.2%)

24 (61.5%)

4 (10.3%)

   

(c)

Model

TBA

Sign Test (P)

CVC

OR (95% C.I.)

NLRC4 rs212704

0.516

6 (0.377)

9/10

2.150 (0.955-4.841)

NLRC4 rs212704 × IL1RN VNTR

0.607

10 (0.001)

10/10

3.018 (1.464-6.219)

NLRC4 rs212704 × NLRC4 rs385076 × IL1RN VNTR

0.612

10 (0.001)

10/10

4.212 (1.981-8.957)

NLRC4 rs212704 × NLRP3 rs10925026 x IL1RN VNTR × IL1B rs1143627

0.530

7 (0.172)

6/10

6.024 (2.795-12.986)

NLRC4 rs212704 × NLRC4 rs7562653 × NLRP3 rs10925026 × IL1RN VNTR × IL1B rs1143627

0.519

6 (0.377)

9/10

12.622 (5.429-29.346)

  1. SNP, single-nucleotide polymorphism; CVC, cross-validation consistency; TBA, testing balanced accuracy.
  2. *Association tests were carried out using UNPHASED41 adjusting for sex and age at sampling. Significant results are shown in bold.
  3. †Significant interaction models are shown in bold.
  4. ‡Global haplotype test, P value=0.092.
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