Figure 2: GC B cells from Eaf2−/− mice show decreased cell death compared with WT GC B cells. | Nature Communications

Figure 2: GC B cells from Eaf2−/− mice show decreased cell death compared with WT GC B cells.

From: EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

Figure 2

Cells from Peyer’s patches (106 cells per ml) were cultured in medium alone or in the presence of CD40L+α-IgM+IL-4 or an agonistic anti-Fas Ab for 6 h and then analysed for cell death as in Fig. 1 in gated GC B cells (a), non-GC B (b) and other immune cells (c). (d) Summary of the results obtained with three pairs of WT and Eaf2−/− mice. Upper panels, 6 h culture; Lower panels, 24 h culture. White bars, WT; Solid bars, Eaf2−/−. *P<0.05; **P<0.01 (paired t-test).

Back to article page