Figure 2: PX-RICS −/− mice display impaired motor coordination and a seizure-prone phenotype. | Nature Communications

Figure 2: PX-RICS −/− mice display impaired motor coordination and a seizure-prone phenotype.

From: PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking

Figure 2

(a) Accelerating rotarod test. PX-RICS−/− mice showed poor motor coordination. (b) Limb-clasping behaviour in PX-RICS−/− mice. When picked up by the tail, PX-RICS+/+ mice splayed their limbs outwards away from the abdomen. In contrast, PX-RICS−/− mice continuously held all four limbs together in a bat-like posture. (c–e) Increased susceptibility to kainate-induced epileptic seizures in PX-RICS−/− mice. (c) Representative time-dependent progression of seizure severity in four pairs of PX-RICS+/+ and PX-RICS−/− littermates. (d) A breakdown of the maximum seizure severity in PX-RICS+/+ and PX-RICS−/− mice. (e) Latency for each seizure stage. Significant differences were not determined in latency to score 6 due to the small number of PX-RICS+/+ mice that reached the stage. n=20 (PX-RICS+/+) and 20 (PX-RICS−/−). Data are represented as means±s.e.m. NS, not significant; **P<0.01; ***P<0.001. Two-way analysis of variance with Bonferroni’s post hoc test (a), χ2-test (d) and unpaired two-tailed Student’s t-test (e).

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