Figure 3: Early response to PHx in MICU1 KD and Ctrl liver.
From: MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
(a) Immunoblot analysis of phosphorylation level of CREB and STAT3 before (LL) and 1 or 6 h after PHx. Quantification of phospho-STAT3 and phospho-CREB is displayed in bar graphs (mean±s.e.m., n=3/group). (b) mRNA fold change of genes, relative to LL, 6 h after PHx. Horizontal lines show mean values. (mean±s.e.m., n=3/group). (c) Serum level of interleukin-6 (IL-6) and tissue level of TNF-α and DNA-binding activity of NF-κB in Ctrl and KD mice 1 and 6 h after PHx (mean±s.e.m., n=3–4/group). (d) Serum levels of ALT, direct and total bilirubin, and triglycerides in Ctrl and KD mice 1 and 6 h post PHx (mean±s.e.m., n=3/group). Values are mean±s.e.m., *P<0.05, **P<0.005, ***P<0.0005 via Mann–Whitney test (c-last panel) and two-way analysis of variance followed by Tukey’s multiple comparison test for the rest.
