Figure 1: Spike-triggered average of LFP (stLFP) indicates the propagating direction of ictal seizures.
From: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
(a–d) Raw spikes (upper panels) and LFPs (lower panels) recorded from representative channels in the DGH (a,c) and MEC (b,d) before (a,b) and after (c,d) kainate. (e–h) DGH spike-triggered averages of DGH LFPs (e,g: DGH–DGH stLFPs, n=5 mice) and MEC spike-triggered averages of MEC LFPs (f,h; MEC–MEC stLFPs, n=6 mice) before (e,f) and after (g,h) kainate. (i–l): Cross-area DGH spike-triggered averages of MEC LFPs (i,k; DGH–MEC stLFPs, n=5 mice) and MEC spike-triggered averages of DGH LFPs (j,l; MEC–DGH stLFPs, n=6 mice) before (i,j) and after (k,l) kainate. (m,n) Averaged peak aptitudes (m) and latencies (n) in stLFPs. Error bars represent s.d. #Represents data not available. (o) Proposed propagation direction of ictal seizures according to the stLFPs.
