Figure 5: Selectively activating DGH GABAergic interneurons decreases beta–gamma-band LFP coherence.
From: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
(a,b,e,f) LFP coherence spectrum (a,e) and mean coherence (b,f) between the DGH and MEC before kainate administration (n=10 mice). (c,d,g,h) LFP coherence spectrum (c,g) and mean coherence (d,h) between the DGH and MEC after kainate administration (n=10 mice). Light pulses (473 nm, 5 ms pulse duration at 130 Hz) were delivered into the DGH (a–d) and MEC (e–h) at time 0.Insets show the targeting sites for optical stimulation and electrical recording. Thick blue lines denote the 60-s stimulation periods. Error bars represent s.e.m. Stars represent significant differences (P<0.01, paired t-test).
