Figure 3: CK but not its close homologue MYO28B is required for DRONC activation and the suppression of extra macrochaete in the scutellum. | Nature Communications

Figure 3: CK but not its close homologue MYO28B is required for DRONC activation and the suppression of extra macrochaete in the scutellum.

From: The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

Figure 3

(a) Schematic diagram depicting the regulation of normal SOP cell number. (b–d) Light microscope images of macrochaete in the scutellum of the adult notum. White arrows indicate ectopic macrochaete. Genotypes: (b) Canton S. (c) UAS-DmIKKɛ-IR/sca-Gal4. (d) sca-Gal4/+; UAS-ck-IR/+. (e) Quantification of the number of ectopic macrochaete on the notum of adult flies of the indicated genotypes. *P-value <0.05 with respect to the control and **P-value <0.005 with respect to the control. P-values were calculated using Fisher’s exact test. Genotypes: Control RNAi: UAS-GFP-IR/sca-Gal4. Dronc RNAi: UAS-Dronc-IR/sca-Gal4. DmIKKɛ RNAi: as in c. sgg RNAi: UAS-sgg-IR/sca-Gal4. ck RNAi as in d. myo28B RNAi: UAS-myo28B-IR/sca-Gal4. Control: UAS-GFP:LacZ-nls/sca-Gal4. diap1: UAS-diap1/sca-Gal4. DmIKKɛG250D: sca-Gal4/+; UAS-DmIKKɛG250D/+. ckTAIL: sca-Gal4/+; UAS-ckTAIL/+. ckTAIL+DmIKKɛ RNAi: UAS-DmIKKɛ-IR/sca-Gal4; UAS-ckTAIL/+.

Back to article page