Figure 9: Schematic model depicting the evolutionary conserved and unifying principle of caspase-mediated regulation of kinases. | Nature Communications

Figure 9: Schematic model depicting the evolutionary conserved and unifying principle of caspase-mediated regulation of kinases.

From: The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

Figure 9

In Drosophila, binding of CK to DRONC favours DRONC-mediated cleavage and maturation of SGG46 into its active form SGG10. In mammals, MYO7A might regulate CASP8-mediated cleavage of RIPK1, which results in disassembly of the ripoptosome complex. In the absence of MYO7A, less RIPK1 would be cleaved, which results in a build-up of complex-II/ripoptosome formation, which in turn would lead to enhanced caspase activation.

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