Figure 1: CARD9 is important for the development of autoantibody-induced arthritis. | Nature Communications

Figure 1: CARD9 is important for the development of autoantibody-induced arthritis.

From: Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Figure 1

Intact wild type (WT), Card9−/− (a–d) or Card9−/− (EUCOMM) (e,f) mice were injected with B × N (control) or K/B × N (arthritic) serum i.p. on day 0. Arthritis development was followed by photographing on day 7 (a), clinical scoring of the hind limbs (b,e), ankle-thickness measurement (c,f) and an articular function test (hanging on a wire grid; (d)). Images are representative of, and quantitative data show mean and s.e.m. from 8 to 9 control and 12 to 13 arthritic serum-treated individual mice per group from four independent experiments (a–d) or 5 to 6 control and 8 to 9 arthritic serum-treated mice per group from three independent experiments (e,f). (d) Results from functional test performed 12 times on each mouse between days 7–10. *P<0.05 (two-way ANOVA); see the text for actual P values.

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