Table 1 Characteristics of study participants.

From: Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

Study

N

Study year

Age (s.d.)

Age range

Male (%)

Spherical equivalent

Europeans (n=40,036)

 ALIENOR

509

2006–2008

79.2 (4.1)

73–93

43.2

0.98 (1.98)

 ALSPAC

1,865

1999–2000

45.9 (4.5)

32–59

0

−0.76 (2.16)

 AREDS

1,842

1992

68.1 (4.7)

55–81

41.0

0.54 (2.15)

 BATS

383

1992–2013

24.8 (7.8)

20–67

41.3

−0.67 (1.58)

 BMES

1,896

1992–2009

66.8 (8.9)

49–94

43.8

0.58 (1.94)

 CROATIA-Korcula

807

2007–2008

56.2 (13.3)

25–94

34.9

−0.13 (1.59)

 CROATIA-Split

787

2008–2009

51.9 (13.0)

25–80

38.6

−1.27 (1.59)

 DCCT

1,057

1982–1993

35.4 (5.8)

25–49

54.1

−1.47 (1.80)

 EGCUT

904

2002–2013

56 (17.0)

25–99

38.8

0.33 (3.36)

 EPIC

1,083

2004–2011

68.8 (7.5)

50–88

43.8

0.34 (2.27)

 ERF

2,604

2002–2005

48.9 (14.4)

25–87

45.0

0.12 (2.03)

 FES

2,479

1973–1975/ 1989–1991

54.8 (9.3)

28–84

55.3

0.27 (2.37)

 FITSA

188

2000–2001

68.5 (3.3)

63–76

0

1.44 (2.08)

 GHS1

3,178

2007–2008

55.3 (10.9)

35–74

50.4

−0.38 (2.47)

 GHS2

1,354

2008

54.6 (10.8)

36–74

49.6

−0.39 (2.51)

 KORA

2326

2004–2006

55.1 (11.8)

35–84

49.4

−0.26 (2.18)

 OGP Talana

456

2002

52.6 (16.3)

25–89

57.3

−0.20 (0.24)

 ORCADES

1,124

2009

56.5 (13.2)

29–92

39.1

0.10 (2.07)

 RAINE

348

2010–2012

20.4 (0.34)

20–22

49.1

0.03 (1.29)

 RS1

5,702

1991–1993

68.7 (8.7)

55–99

41.0

0.83 (2.55)

 RS2

2,021

2000–2002

64.3 (7.9)

55–95

46.0

0.48 (2.51)

 RS3

2,918

2006–2009

56.9 (6.6)

45–86

44.0

−0.28 (2.60)

 TwinsUK

2,154

1998–2010

53.8 (11.4)

25–84

8.4

−0.96 (2.78)

 WESDR

561

1979–2007

31.7 (7.0)

25–65

50.3

−1.65 (2.07)

 YFS

1,490

2011

41.9 (5.0)

34–49

44.6

−1.09 (2.16)

Asians (n=10,315)

 BES

589

2006–2011

62.1 (8.5)

50–90

34.0

−0.06 (1.86)

 Nagahama

723

2008–2010

49.2 (15.2)

30–74

33.6

−1.93 (2.46)

 SCES-610K

1,710

2009–2011

57.5 (7.0)

44–84

51.6

−0.72 (2.69)

 SCES-OmniE

543

2011–2012

59.3 (8.9)

46–83

51.2

−0.89 (2.74)

 SiMES

2,256

2004–2006

46.8 (10.2)

40–80

49.1

−0.03 (1.81)

 SINDI

2,088

2007–2009

55.8 (8.8)

43–84

51.5

0.04 (2.07)

 SP2-1M

811

1992–1998

46.8 (10.2)

25–80

62.3

−1.80 (2.84)

 SP2-610

854

1992–1998

48.4(11.3)

25–82

19.6

−1.44 (2.89)

 STARS

741

2007–2009

38.5 (5.2)

26–58

52.4

−2.80 (2.85)

  1. ALIENOR, antioxydants, lipids essentiels, nutrition et maladies oculaiRes; ALSPAC, avon longitudinal study of parents and children; AREDS, age-related eye disease study; BATS, Brisbane adolescent twins study; BMES, blue mountains eye study; DCCT, diabetes control and complications trial; EGCUT, estonian genome center of the university of Tartu; EPIC, EPIC-Norfolk eye study; ERF, erasmus rucphen family study; FES, Framingham eye study; FITSA, finnish twin study on aging; GHS, Gutenberg health study; KORA, cooperative health research in the region of Augsburg; OGP Talana, ogliastra genetic park, talana study; ORCADES, orkney complex disease study; RAINE, RAINE eye health study; RS, Rotterdam study; TwinsUK, Twins UK study; WESDR, Wisconsin epidemiologic study of diabetic retinopathy; YFS, young finns study; BES, Beijing eye study; SCES, Singapore Chinese eye study; SiMES, Singapore Malay eye study; SINDI, Singapore Indian eye study; SP2, Singapore prospective study program; STARS, strabismus, amblyopia and refractive error study in preschool singaporean children. s.d., standard deviation; age in years; spherical equivalent in dioptres.
  2. Details of each study cohort are described in Supplementary Note 1.