Table 2 Six genetic loci associated with spherical equivalent from the JMA in the European populations and combined analyses.

From: Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

SNP (Chr:BP)

Gene

Allele

FREQ

Subgroup

Europeans (n=40,036)

Asians (n=10,315)

All (n=50,351)

     

β

P-value

P het

β

P-value

P het

β

P-value

P het

rs60843830 (2:286756)

FAM150B-ACP1

C/G

0.66/0.74

JMA

 

3.71 × 10−8

0.086

 

0.031

0.980

 

1.27 × 10−9

0.395

    

Lower education

−0.11

4.73 × 10−8

 

−0.09

0.010

 

−0.10

1.65 × 10−9

 
    

Higher education

−0.09

1.75 × 10−6

 

−0.06

0.509

 

−0.09

9.83 × 10−7

 

rs10946507 (6:22100367)

LINC00340 (6p22.3)

A/G

0.47/0.16

JMA

 

3.07 × 10−8

0.213

 

0.433

0.396

 

2.24 × 10−8

0.249

    

Lower education

−0.08

7.08 × 10−7

 

−0.04

0.313

 

−0.08

6.13 × 10−7

 
    

Higher education

−0.09

1.19 × 10−8

 

−0.08

0.450

 

−0.09

1.20 × 10−8

 

rs8023401 (15:48703823)

FBN1

G/A

0.87/0.95

JMA

 

1.66 × 10−9

0.180

 

0.572

0.979

 

2.85 × 10−9

0.495

    

Lower education

−0.15

4.40 × 10−8

 

−0.06

0.304

 

−0.13

8.17 × 10−8

 
    

Higher education

−0.16

7.61 × 10−11

 

−0.03

0.828

 

−0.14

2.02 × 10−9

 

rs16949788 (15:66590037)

DIS3L-MAP2K1

T/C

0.91/0.94

JMA

 

1.34 × 10−8

0.721

 

0.0042

0.219

 

2.19 × 10−8

0.245

    

Lower education

−0.15

1.35 × 10−6

 

0.21

0.103

 

−0.13

4.88 × 10−6

 
    

Higher education

−0.17

1.89 × 10−9

 

−0.59

0.014

 

−0.16

3.90 × 10−9

 

rs10880855 (12:46144855)

ARID2-SNAT1

T/C

0.51/0.43

JMA

 

7.83 × 10−7

0.790

 

0.019

0.779

 

4.38 × 10−8

0.867

    

Lower education

−0.09

1.26 × 10−7

 

−0.06

0.067

 

−0.09

8.42 × 10−9

 
    

Higher education

−0.07

1.60 × 10−5

 

−0.16

0.033

 

−0.07

3.55 × 10−6

 

rs10853531 (18:42824449)

SLC14A2

G/A

0.80/0.83

JMA

 

7.82 × 10−6

0.052

 

0.0023

0.812

 

2.54 × 10−8

0.111

    

Lower education

−0.11

1.27 × 10−6

 

−0.15

9.01 × 10−4

 

−0.11

3.38 × 10−9

 
    

Higher education

−0.08

2.12 × 10−6

 

−0.11

0.288

 

−0.09

7.14 × 10−6

 
  1. β, β-coefficient corresponds to the effect in spherical equivalent (dioptres) for 1 additional copy of the risk allele in the higher or lower education group. FREQ, allele frequency of the risk allele in European/Asian cohorts; JMA, joint meta-analysis on SNP effect and SNP × education interaction effect on spherical equivalent; Phet, P-value for the test of heterogeneity at each SNP; SNP, single-nucleotide polymorphism. Allele, risk allele/other allele.
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