Figure 7: Schematic diagram for the regulation of PGRMC1 functions. | Nature Communications

Figure 7: Schematic diagram for the regulation of PGRMC1 functions.

From: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Figure 7

Apo-PGRMC1 exists as an inactive monomer. On binding to haem, PGRMC1 forms a dimer through stacking interactions between the haem moieties, which enables PGRMC1 to interact with EGFR and cytochromes P450, leading to an enhanced proliferation and chemoresistance of cancer cells. CO interferes with the stacking interactions of the haems and thereby inhibits PGRMC1 functions.

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