Figure 2: Synthesis and crystal structure of disulfide dimer and tetrahedron.
From: A facile route to old and new cyclophanes via self-assembly and capture
(a) Pnictogen-activated iodine oxidation of H3L3 cleanly forms disulfide macrobicycle L32 (dimer, 69%) and tetrahedron L34 (tetramer, 29%) in combined 98% isolated yield at ∼2 mM concentration (1 equiv H3L3, 2.5 equiv SbCl3; 3 equiv I2). Single-crystal X-ray structure representations of tetrahedron L34 (b) (thermal ellipsoids at 50%) and dimer L32 (c) (thermal ellipsoids at 30%). Hydrogen atoms and solvents of crystallization have been omitted for clarity.
