Figure 3: Chemoselective Suzuki–Miyaura cross-coupling of chiral 1,2-diboronic esters.
From: Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures
(a) Demonstration of selective coupling of linear boronic ester, while the branched B–C bond remains intact. (b) Stereoretentive coupling of remaining secondary benzylic B–C bond in enantioenriched boronic esters, leading to enantiomerically enriched unsymmetrical 1,1′,2-triarylethanes with up to 92% enantiospecificity.
