Figure 1: The log likelihood of the proportion infected per bite after experimental challenge to infectious mosquitoes.

Data were assembled from the non-intervention arms of vaccine and drug trials in carefully monitored studies using human subjects previously unexposed to malaria (Table 1). The thin solid line uses only the data for which an exact number of infectious bites were reported. The two dashed lines use the upper or lower bound or the upper bound for the number of infectious bites. The solid line uses the average of the log likelihood from the upper and lower bound. In people previously unexposed to malaria, the ratio of the FOI to the EIR is ∼55%, with confidence limits between 47 and 63%.