Figure 3: Expansion and diversification of the FIKK multigene family in the Laverania subgenus. | Nature Communications

Figure 3: Expansion and diversification of the FIKK multigene family in the Laverania subgenus.

From: Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria

Figure 3

(a) Phylogeny of FIKK genes from P. falciparum (green), P. reichenowi (red), P. gaboni (blue) and non-Laverania species (black). FIKK genes are labelled according to their P. falciparum orthologues, with the new P. gaboni gene designated FIKK9.15. Open symbols indicate pseudogenes in all members of the species (FIKK7.2 is intact in some strains of P. falciparum). The tree was inferred using maximum likelihood methods69 using an alignment of first and second codon positions. Internal branches with bootstrap support of <70% are collapsed. Scale bar, 0.05 substitutions per site. (b) Expression profiles of P. falciparum FIKK genes. Previously published microarray data23 from 21 clonal P. falciparum strains were used to calculate the expression levels of 19 FIKK genes at different time points during the intra-erythrocytic lifecycle (data for the remaining FIKK gene were not available). Colours represent mRNA expression levels relative to a reference pool, with red, black and green indicating higher, equal and lower expression levels than the reference pool, respectively. Genes were arranged to illustrate the sequential nature of FIKK gene expression.

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