Figure 3: Variance explained by SNPs and longitudinal stability.
From: Genetic and environmental influences interact with age and sex in shaping the human methylome
(a) Histogram of total additive heritability (h2 total) of DNA methylation (green) and variance explained by genome-wide SNPs (h2 SNPs, purple) for genome-wide CpGs. The y axis is truncated. (b) Density plot of methylation sites with a high versus low heritability. (c) Distribution of methylation sites grouped based on heritability and longitudinal stability relative to genes: DP, distal promoter; DS, downstream region; GB, gene body; IG, intergenic; PP, proximal promoter. (d) Distribution of methylation sites grouped based on heritability and longitudinal stability in relation to CpG density: CGI, CpG island; NC, non-CGI; SHE, CpG island shelf; SHO, CpG island shore. Asterisks denote significant enrichment or depletion (α=4.27 × 10−4, χ2-test). Results of DNA methylation heritability are from the GRM-based approach in 2,603 individuals. Longitudinal stability was assessed in 31 subjects with data from two longitudinally collected blood samples.
