Figure 4: Main effects of age and sex and their interaction with genetic and environmental effects.
From: Genetic and environmental influences interact with age and sex in shaping the human methylome
(a) Main and interaction effects of sex. The x axis denotes chromosomal position. The y axis denotes the β-value from the regression of methylation M value on sex (while correcting for age, white blood cell counts and technical covariates). Sites where the genetic variance showed significant sex interaction are indicated in blue. Sites where the environmental variance showed significant sex interaction are shown in green. The y axis is truncated at −1 and 1 to improve visibility, excluding a small number of sites with regression β-values up to −2.4 and 2.6. (b) Mean and interaction effects of age. The x axis denotes chromosomal position. The y axis denotes the β-value from the regression of methylation M value on age (while correcting for sex, white blood cell counts and technical covariates). Sites where the genetic variance showed significant age interaction are indicated in blue. Sites where the environmental variance showed significant age interaction are shown in green. Results are based on data from 2,603 individuals.
